Is this thing even human? The same thing can apply to Devastators, but The Ruin is much larger and has more health that a Devastator. Nukes are ineffective unless you use about 4-5 of them, but the MGL Turret's Hand of Ra will put a hurting on this thing. Also effective are any of the second to last upgrades on path 1 of every tower except the special turret. If The Ruin gets through your defenses, it's game over.